Journal article
Fatal and Nonfatal Events Within 14 days After Early, Intensive Mobilization Poststroke
J Bernhardt, K Borschmann, JM Collier, AG Thrift, P Langhorne, S Middleton, RI Lindley, HM Dewey, P Bath, CM Said, L Churilov, F Ellery, C Bladin, CM Reid, JH Frayne, V Srikanth, SJ Read, GA Donnan
Neurology | Published : 2021
Abstract
Objective This tertiary analysis from A Very Early Rehabilitation Trial (AVERT) examined fatal and nonfatal serious adverse events (SAEs) at 14 days. Method AVERT was a prospective, parallel group, assessor blinded, randomized international clinical trial comparing mobility training commenced 80 years subgroups, but there was no significant treatment by subgroup interaction. No difference in nonfatal SAEs was found. Conclusion While the overall case fatality at 14 days poststroke was only 3.8%, mortality adjusted for age and stroke severity was increased with high dose and intensive training compared to usual care. Stroke progression was more common in VEM.
Grants
Awarded by Stroke Association
Funding Acknowledgements
Supported by National Health and Medical Council Australia (386201, 1041401), Chest Heart and Stroke Scotland (Res08/A114), Northern Ireland Chest Heart and Stroke, Singapore Health (SHF/FG401P/2008), UK Stroke Association (TSA2009/09), UK National Institute Health Research (Health Technology Assessment Project 12/01/16), and Australian Research Council (0991086).